Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) play a critical role in gastric cancer (GC) progression and metastasis. However, research comprehensively exploring tissue-derived lncRNAs for predicting peritoneal recurrence in patients with GC remains limited. This study aims to investigate the transcriptional landscape of lncRNAs in GC with peritoneal metastasis (PM) and to develop an integrated lncRNA-based score to predict peritoneal recurrence in patients with GC after radical gastrectomy.

Methods

We analyzed the transcriptome profile of lncRNAs in paired peritoneal, primary gastric tumor, and normal tissue specimens from 12 patients with GC in the Sun Yat-sen University Cancer Center (SYSUCC) discovery cohort. Key lncRNAs were identified via interactive analysis with the TCGA

SUBMITTER: Cai XX 

PROVIDER: S-EPMC11686839 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature