Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort study.

ABSTRACT:

Background

Hip fracture is common and associated with high morbidity and mortality rates. Selective serotonin reuptake inhibitors (SSRIs) influence platelet hemostasis and might result in abnormal bleeding. This study aims to determine whether the use of SSRIs in older patients undergoing hip fracture surgery is associated with the risk of perioperative red blood cell (RBC) transfusion.

Methods

We conducted a retrospective observational study using prospectively collected data of patients aged 70 years and older admitted to a French geriatric perioperative ward for hip fracture between January 2012 and June 2021. The primary endpoint was the occurrence of RBC transfusion during hospitalization. Multivariate logistic regression was performed, with a sensitivity analysis accor

SUBMITTER: Gobillot-Morisson H 

PROVIDER: S-EPMC11686848 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature