A meta-analysis and systematic review of myocardial infarction-induced cardiomyocyte proliferation in adult mouse heart.

ABSTRACT:

Background

The proliferation capacity of adult cardiomyocytes is very limited in the normal adult mammalian heart. Previous studies implied that cardiomyocyte proliferation increases after injury stimulation, but the result is controversial partly due to different methodologies. We aim to evaluate whether myocardial infarction (MI) stimulates cardiomyocyte proliferation in adult mice.

Methods

A comprehensive literature search was conducted through PubMed/Medline, Embase, and Web of Science databases from 1 January 2000 to 21 December 2023. The SYRCLE's Risk of Bias tool for animal experiments was used to evaluate the quality of the literature by two independent reviewers. Twenty-six studies with cell cycle indicators (Ki67⁺, PH3⁺, BrdU/EdU⁺,

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11686908 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature