Designing multi-epitope vaccines against Echinococcus granulosus: an in-silico study using immuno-informatics.

ABSTRACT: Cystic echinococcosis (CE) is a worldwide zoonotic public health issue. The reasons for this include a lack of specific therapy options, increasing antiparasitic drug resistance, a lack of control strategies, and the absence of an approved vaccine. The aim of the current study is to develop a multiepitope vaccine against CE by in-silico identification and using different Antigen B subunits. The five Echinococcus granulosus antigen B (EgAgB) subunits were examined for eminent antigenic epitopes, and then the best B-cell and Major Histocompatibility Complex MHC-binding epitopes were predicted. Most significant epitopes were combined to create an effective multi-epitope vaccine, which was then validated by testing its secondary and tertiary structures, physicochemical properties, and molecula

SUBMITTER: Khan J 

PROVIDER: S-EPMC11686936 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature