The plasma metabolome of juvenile idiopathic arthritis varies according to subtype and underlying inflammatory status.

ABSTRACT:

Background

Juvenile idiopathic arthritis (JIA) is challenging to classify and effectively monitor due to the lack of disease- and subtype-specific biomarkers. A robust molecular signature that tracks with specific JIA features over time is urgently required, and targeted plasma metabolomics may reveal such a signature. The primary aim of this study was to characterise the differences in the plasma metabolome between JIA patients and non-JIA controls and identify specific markers of JIA subtype. We also assessed the extent to which these signatures are due to underlying inflammation as assessed by glycoprotein acetyls (GlycA) and high-sensitivity C-Reactive Protein (hsCRP) levels.

Methods

Targeted nuclear magnetic resonance (NMR) metabolomic profiles of plasma of 72 children

SUBMITTER: Kwon J 

PROVIDER: S-EPMC11686955 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature