Impaired pulmonary function increases the risk of gout: evidence from a large cohort study in the UK Biobank.

ABSTRACT:

Background

Pulmonary function is increasingly recognized as a key factor in metabolic diseases. However, its link to gout risk remains unclear. The study aimed to investigate the relationship between pulmonary function and the risk of developing gout and the underlying biological mechanisms.

Methods

Our study included 420,002 participants with complete pulmonary function data from the UK Biobank. Logistic regression was used to evaluate gout prevalence among individuals with different pulmonary function statuses. Propensity score matching (PSM) created balanced groups, while Cox regression gauged the risk association between reduced lung capacity and gout compared with normal function. Mendelian randomization (MR) analysis was used to verify causal associations. Non-linear c

SUBMITTER: Kang Z 

PROVIDER: S-EPMC11686989 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature