Development and internal validation of a prognostic model for predicting tonic-clonic seizures during pregnancy in women with epilepsy.

ABSTRACT:

Background

We aim to develop a model to predict the probability of tonic-clonic seizures in women with epilepsy (WWE) at any point during pregnancy until six weeks postpartum.

Methods

We conducted a screening of patients diagnosed with epilepsy and who were pregnant, at a tertiary hospital in China, during the period of 1 January 2010 to 31 December 2020. We then followed up with these patients for at least one year postpartum. A total of 271 eligible patients were included in the cohort. The outcome was the occurrence of a tonic-clonic seizure during pregnancy or within six weeks postpartum. Predictors were screened through univariate analysis, and models were fitted through multivariate logistic regression analysis. Further, we compared the WMU model with the AntiEpileptic

SUBMITTER: Du Y 

PROVIDER: S-EPMC11687190 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature