Impact of renal replacement therapy modality on coagulation and platelet function in critically ill patients: A prospective observational study.

ABSTRACT:

Background

Renal replacement therapy (RRT) may affect coagulation and platelet function in critically ill patients. However, the mechanism and the difference in the impact on coagulation between intermittent hemodialysis (iHD) and continuous renal replacement therapy (CRRT) remains unclear. This study aimed to investigate and compare the impact of iHD and CRRT on coagulation and platelet function.

Methods

Critically ill patients undergoing RRT were classified into the iHD group or the CRRT group. After the first blood sampling, patients underwent either a single session of hemodialysis or 48 h of CRRT, then a second blood sample was taken. Rotational thromboelastometry (ROTEM), platelet aggregometry and conventional coagulation tests were performed. The primary outcome was a

SUBMITTER: Im H 

PROVIDER: S-EPMC11687214 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature