Cardiac automaticity is modulated by IKACh in sinoatrial node during pregnancy.

ABSTRACT:

Aims

Pregnant (P) women have a significantly elevated resting heart rate (HR), which makes cardiac arrhythmias more likely to occur. Although electrical remodelling of the sinoatrial node (SAN) has been documented, the underlying mechanism is not fully understood. The acetylcholine-activated potassium current (IKACh), one of the major repolarizing currents in the SAN, plays a critical role in HR control by hyperpolarizing the maximal diastolic potential (MDP) of the SAN action potential (AP), thereby reducing SAN automaticity and HR. Thus, considering its essential role in cardiac automaticity, this study aims to determine whether changes in IKACh are potentially involved in the increased HR associated with pregnancy.

Methods and results

Experiments were conducted on non-pre

SUBMITTER: Long V 

PROVIDER: S-EPMC11687396 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature