MiR-595 and Cldnd1: Potential related factors for bone loss in postmenopausal women with hip osteoporotic fracture.

ABSTRACT:

Background

Recently researches have reported that miRNA and its target genes are associated with osteoporosis. MiRNA and mRNA might be potential diagnostic markers for osteoporosis.

Purposes

The aim of this study is to explore the potential miRNA and mRNA markers by bioinformatics method and clinical analysis.

Patients and methods

The miRNA expression profiles were obtained from GSE74209, GSE64433 and GSE115773 in Gene expression Omnibus (GEO). The mRNA expression profiles were obtained from GSE100609. Wayne intersection were used to explore the different expressed miRNAs (DE-miRs). Select the miRNA with the highest Fold Change for subsequent research. Screening of miRNA target genes using TargetScan and miRDB tools. GO and KEGG analyses of target genes (TGs) function

SUBMITTER: Jingyue S 

PROVIDER: S-EPMC11687715 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature