The dysregulation of PARP9 expression is linked to apoptosis and DNA damage in gastric cancer cells.

ABSTRACT:

Background

Gastric cancer (GC) is a highly malignant gastrointestinal tumor characterized by difficult early diagnosis and poor prognosis. Therefore, it is imperative to explore potential therapeutic targets for gastric cancer. PARP9 is abnormally expressed in a variety of tumors and is associated with tumor cell apoptosis and DNA damage. However, its relationship with GC has not been fully studied.

Methods

The expression and prognostic significance of PARP9 in gastric cancer (GC) were examined using bioinformatics approaches. Cell lines with either knockdown or overexpression of PARP9 were established through lentiviral transduction, and the role of PARP9 in the malignant phenotypes of GC cells was validated via CCK8 assays, wound healing assays, clonogenic assays, and Tran

SUBMITTER: Li Y 

PROVIDER: S-EPMC11687892 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature