Model supports asymmetric regulation across the intercellular junction for collective cell polarization.

ABSTRACT: Symmetry breaking, which is ubiquitous in biological cells, functionally enables directed cell movement and organized embryogenesis. Prior to movement, cells break symmetry to form a well-defined cell front and rear in a process called polarization. In developing and regenerating tissues, collective cell movement requires the coordination of the polarity of the migration machineries of neighboring cells. Though several works shed light on the molecular basis of polarity, fewer studies have focused on the regulation across the cell-cell junction required for collective polarization, thus limiting our ability to connect tissue-level dynamics to subcellular interactions. Here, we investigated how polarity signals are communicated from one cell to its neighbor to ensure coordinated front-to-re

SUBMITTER: Levandosky K 

PROVIDER: S-EPMC11687927 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature