Human albumin for adults with sepsis: An updated systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Sepsis affects millions of people and imposes a substantial economic and social burden worldwide. However, the role of human albumin in the management of septic patients remains unclear.

Methods

EMBASE, PubMed, and Cochrane Library databases were searched. Randomized controlled trials regarding the use of human albumin in septic patients were eligible. The overall mortality and the intensive care unit (ICU), in-hospital/28-day, and 90-day mortality were pooled, respectively. Subgroup analyses were performed according to target population, type and dose of human albumin, and type of control group. Risk ratios (RRs) was calculated.

Results

Twenty-four randomized controlled trials were finally included. Meta-analysis showed that human albumin cannot decrease t

SUBMITTER: Bai Z 

PROVIDER: S-EPMC11687998 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature