Exploring causal relationship between the lipids, immune cells, and leiomyosarcoma: A Mendelian randomization and mediation analysis.

ABSTRACT: This study aimed to delineate the causal nexus between lipids and leiomyosarcoma (LMS), with a particular emphasis on delineating the mediating role of immune cells. Employing a 2-sample Mendelian randomization (MR) framework, we scrutinized the potential association of 179 lipid species with LMS across 179 cases and 314,193 controls. The analysis was underpinned by summary-level data derived from genome-wide association studies. The inverse variance weighting method constituted our primary analytical strategy, augmented by supplementary techniques including MR-Egger, simple mode, weighted median, and weighted mode. To ensure the integrity of our MR inferences, we conducted rigorous horizontal multiplicity, heterogeneity, and Bayesian assessments. Furthermore, a nuanced 2-step Mendelian an

SUBMITTER: Jin X 

PROVIDER: S-EPMC11688058 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature