Absence of genetic association between insulin-like growth factors and esophageal cancer.

ABSTRACT: This study aimed to explore the causal relationship between concentrations of various insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) and esophageal cancer (ESC), addressing the gap in understanding the genetic link between IGF1 and ESC. A two-sample Mendelian randomization (MR) analysis was conducted using single nucleotide polymorphisms linked to IGFs/IGFBPs and ESC from the IEU Open GWAS Project. This analysis included ESC GWAS data from 1996 individuals of European descent and genetic variant data from 3310 individuals of European ancestry. Various methods, such as inverse variance weighting, weighted median, weighted mode, and MR-Egger regression, were applied for analysis, with sensitivity assessments including MR-PRESSO, Cochran Q, and leave-one-out analysis to

SUBMITTER: Sun Z 

PROVIDER: S-EPMC11688069 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature