Brain 18FDG-PET pattern in cognitively impaired elderly patients with bipolar disorder.

ABSTRACT:

Background

Patients with bipolar disorder (BD) are at increased risk of dementia. The underlying mechanisms are debated. FDG-PET elucidates glucose metabolic reductions due to altered neuronal activity in the cerebral cortex, allowing detection and identification of neurodegenerative processes. This study aims to investigate cerebral glucose metabolism in cognitively impaired elderly patients with BD using FDG-PET imaging, to elucidate potential underlying mechanisms and improve diagnostic accuracy.

Methods

We conducted a retrospective analysis of FDG-PET scans from 32 cognitively impaired elderly patients with BD (mean age 70.4 years). These were compared with scans from 35 non-degenerative controls (NDC) and patients diagnosed with Alzheimer's disease (AD, n = 27), frontot

SUBMITTER: Saleh N 

PROVIDER: S-EPMC11688258 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature