ACE2 and TMPRSS2 genetic polymorphisms as potential predictors of COVID-19 severity and outcome in females.

ABSTRACT:

Introduction

ACE2 and TMPRSS2 represent the major gateways for SARS-CoV-2 cell entry. The presence of functional ACE2 and TMPRSS2 genetic polymorphisms that affect gene expression may affect the risk of severe form of COVID-19 and its fatal outcome.

Material and patients

This observational study enrolled 178 hospitalized patients diagnosed with SARS-CoV-2 infection at the University Clinical Centre of Kragujevac, Serbia. Demographic, clinical, and laboratory data were gathered at admission. Genotyping for single nucleotide polymorphisms of ACE2 (rs2106809 and rs2074192) and TMPRSS2 (rs2070788 and rs4818239) was performed using the Real-Time PCR method with TaqMan assays.

Results

Controlling for other factors of influence, such as CCI, N/L ratio, LDH leve

SUBMITTER: Matic S 

PROVIDER: S-EPMC11688283 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature