Antigen-antibody complex density and antibody-induced HLA protein unfolding influence Fc-mediated antibody effector function.

ABSTRACT: Donor-specific antibodies (DSAs) targeting mismatched human leukocyte antigen (HLA) molecules are one of the principal threats to long-term graft survival in solid organ transplantation. However, many patients with long-term circulating DSAs do not manifest rejection responses, suggesting a degree of heterogeneity in their pathogenicity and related functional activity. Immunologic risk stratification of transplant recipients is complicated by challenges intrinsic to defining alloantibody responses that are potentially pathogenic versus those that are not. Thus, a comprehensive understanding of how human alloantibodies target and interact with donor HLA molecules is vital for the development and evaluation of new strategies aimed at reducing antibody-mediated rejection responses. In this st

SUBMITTER: Murali TM 

PROVIDER: S-EPMC11688311 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature