Integrated transcriptomic analysis reveals evolutionary and developmental characteristics of tendon ossification in teleost.

ABSTRACT:

Background

Intermuscular bones (IBs) are segmental intramembranous ossifications located within myosepta. They share similarities with tendon ossification, a form of heterotopic ossification (HO). The mechanisms underlying IB formation remain incompletely understood.

Results

In this study, we systematically analyzed transcriptome data across multiple tissues, species, time points, and resolutions in teleosts. First, we identified IB-specific expression genes using the tau index method. Through cross-species comparisons of the tendon development process, we discovered that candidate genes were primarily enriched in extracellular matrix organization, ossification, regulation of angiogenesis, and other related processes. We also revealed that some of these candidate genes are a

SUBMITTER: Wang XD 

PROVIDER: S-EPMC11689531 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature