Blood-derived APLP1⁺ extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases.

ABSTRACT: The early detection of neurodegenerative diseases necessitates the identification of specific brain-derived biomolecules in peripheral blood. In this context, our investigation delineates the role of amyloid precursor-like protein 1 (APLP1)-a protein predominantly localized in oligodendrocytes and neurons-as a previously unidentified biomarker in extracellular vesicles (EVs). Through rigorous analysis, APLP1⁺ EVs from human sera were unequivocally determined to be of cerebral origin. This assertion was corroborated by distinctive small RNA expression patterns of APLP1⁺ EVs. The miRNAs' putative targets within these EVs manifested pronounced expression in the brain, fortifying their neurospecific provenance. We subjected our findings to stringent validation using Thy-1

SUBMITTER: Choi Y 

PROVIDER: S-EPMC11691634 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature