A meta-analysis and polygenic score study identifies novel genetic markers for waist-hip ratio in African populations.

ABSTRACT:

Objective

Understanding the genetic underpinnings of anthropometric traits in diverse populations is crucial for gaining insights into their biological mechanisms and potential implications for health.

Methods

We conducted a genome-wide association study, meta-analysis, and gene set analysis of waist-hip ratio (WHR), WHR adjusted for BMI (WHRadjBMI), waist circumference, BMI, and height using the African Collaborative Center for Microbiome and Genomics Research (ACCME) cohort (n = ~11,000) for discovery and polygenic score target analyses and the Africa America Diabetes Mellitus (AADM) study (n = ~5200) for replication and polygenic score validation. We generated and compared polygenic scores from European, African, Afro-Caribbean, and multiethnic ancestry populations.

Re

SUBMITTER: Zhong M 

PROVIDER: S-EPMC11692486 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature