GSK3β Deficiency Expands Obese Adipose Vasculature to Mitigate Metabolic Disorders.

ABSTRACT:

Background

Maintaining a well-developed vascular system alongside adipose tissue (AT) expansion significantly reduces the risk of metabolic complications. Although GSK3β (glycogen synthase kinase-3 beta) is known for its role in various cellular processes, its specific functions in AT and regulation of body homeostasis have not been reported.

Methods

GSK3β-floxed and GSK3α-floxed mice were crossed with adiponectin-Cre mice to generate GSK3β or GSK3α adipocyte-specific knockout mice (GSK3β^ADKO and GSK3α^ADKO). A comprehensive whole-body metabolism analysis was performed on obese GSK3β^ADKO mice induced by a high-fat diet. RNA sequencing was conducted on AT of both obese GSK3β^ADKO and GSK3α^ADKO mice. Various analyses, includ

SUBMITTER: Wang L 

PROVIDER: S-EPMC11692787 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature