Evaluation of Withania somnifera based supplement for immunomodulatory and antiviral properties against viral infection.

ABSTRACT:

Background

Viral mediated diseases are continuously posing potent threat to human health. Nutraceuticals are being employed as novel therapeutics during viral outbreaks. MAM granules consist of Curcuma longa, Withania somnifera, and Piper nigrum, is one such patented Siddha nutraceutical supplement that has been proposed to be a therapeutic agent against viral diseases.

Objective

We characterised MAM for their phytochemical and physicochemical properties and evaluated its cytotoxicity via in vivo acute toxicity studies using Wistar rats and by cell-based MTT assays.

Materials and methods

The antiviral properties of the aqueous extract of MAM were investigated against SARS-CoV-2 and chikungunya virus (CHIKV). Further, using ABTS radical scavenging, SOD enzymatic assays

SUBMITTER: Verma DK 

PROVIDER: S-EPMC11693430 | biostudies-literature | 2024 Sep-Oct

REPOSITORIES: biostudies-literature