Genomic Differences between Spontaneous versus Indicated Extreme Preterm Birth.

ABSTRACT:

Objective

 Extremely preterm infants are at high risk of neonatal mortality and morbidity. Extreme preterm birth (PTB) may result from spontaneous preterm labor or preterm premature rupture of membranes or may be indicated due to preeclampsia, eclampsia, hypertension, or other causes. Our objective was to identify single nucleotide polymorphisms (SNPs) and biological pathways associated with spontaneous versus indicated extreme PTB using the neonatal genome.

Study design

 We evaluated 523 spontaneous births and 134 indicated births weighing 401 to 1,000 g at birth from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's Genomics dataset by genome-wide association study (GWAS) and pathway analysis. The TOLSURF cohort

SUBMITTER: Ambalavanan N 

PROVIDER: S-EPMC11693484 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature