Deciphering network dysregulations and temporo-spatial dynamics in disorders of consciousness: insights from minimum spanning tree analysis.

ABSTRACT:

Objectives

The neural mechanism associated with impaired consciousness is not fully clear. We aim to explore the association between static and dynamic minimum spanning tree (MST) characteristics and neural mechanism underlying impaired consciousness.

Methods

MSTs were constructed based on full-length functional magnetic resonance imaging (fMRI) signals and fMRI signal segments within each time window. Global and local measures of static MSTs, as well as spatio-temporal interaction characteristics of dynamic MSTs were investigated.

Results

A disruption or an alteration in the functional connectivity, the decreased average coupling strength and the reorganization of hub nodes were observed in patients with minimally conscious state (MCS) and patients with vegetative st

SUBMITTER: Dai Y 

PROVIDER: S-EPMC11693494 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature