Factors affecting posaconazole plasma concentrations: a meta-analysis and systematic review.

ABSTRACT:

Background

Posaconazole is a potent antifungal agent widely used to manage invasive fungal infections, especially in immunocompromised individuals. Achieving optimal therapeutic concentrations of posaconazole can be challenging due to interpatient variability, the availability of multiple formulations, and various dosing strategies.

Methods

We conducted a systematic search of PubMed, EMBASE, and the Cochrane Library to identify studies evaluating factors that influence blood concentrations of posaconazole. The primary outcome was the assessment of posaconazole concentrations in relation to various influencing factors, including age, sex, drug interactions, disease state, administered dose, and formulation.

Results

Our analysis included 46 studies involving a total of

SUBMITTER: Qu R 

PROVIDER: S-EPMC11693513 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature