Factors associated with cognitive flexibility in people with opioid-use disorder: a pilot study.

ABSTRACT: The ability to adapt to changing circumstances has strong survival value. Individuals with substance use disorders tend to get "stuck" over-responding to drug-reward signals and pursuing drugs despite negative consequences. A lack of flexibility may be tied to impairments in neurocognition, including learning, memory, and executive function. However, results are often mixed, potentially due to heterogeneity in factors such as mental health, personality traits, or prior adversity. This study aimed to identify which factors influence neurocognitive variations within the opioid use disorder (OUD) population. Based on prior literature, we hypothesized that individuals with OUD would show deficits (vs. controls) in one or more neurocognitive domains, and that these cognitive difficulties might

SUBMITTER: Regier PS 

PROVIDER: S-EPMC11693614 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature