A novel liquid-liquid phase separation-related gene signature for predicting prognosis in colon cancer.

ABSTRACT:

Background

An increasing body of evidence indicates that dysregulation of liquid-liquid phase separation (LLPS) in cellular processes is implicated in the development of diverse tumors. Nevertheless, the association between LLPS and the prognosis, as well as the tumor immune microenvironment, in individuals with colon cancer remains poorly understood.

Methods

We conducted a comprehensive evaluation of the LLPS cluster in 1010 colon cancer samples from the TCGA and GEO databases, utilizing the expression profiles of LLPS-related prognostic differentially expressed genes (DEGs). Subsequently, a LLPS-related gene signature was constructed to calculate the LLPS-related risk score (LRRS) for each individual patient.

Results

Two LLPS subtypes were identified. Substantial va

SUBMITTER: Wang S 

PROVIDER: S-EPMC11693697 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature