Infiltrating macrophages and interferon gamma rather than renal genotype dictate heightened crescentic glomerulonephritis.

ABSTRACT:

Background

Both intrinsic renal cells and immune cells contribute to driving renal inflammation and damage. However, the respective roles of intrinsic renal cells and immune cells in crescentic glomerulonephritis, and the key molecular factors driving pathogenesis are still unclear.

Methods

The roles of intrinsic renal cells and renal infiltrating immune cells in crescent formation were explored using renal transplantation after experimental anti-GBM disease induction in 129x1/svJ and C57BL/6J mice. Both strains share MHC, but vary in anti-GBM nephritis susceptibility. The role of macrophage and IFN-γ in crescent formation was investigated using adoptive transfer of macrophages with altered IFN-γ expression. The gene expression profile difference between 129x1/svJ and C57BL/

SUBMITTER: Du Y 

PROVIDER: S-EPMC11693704 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature