SPATS2L is a positive feedback regulator of the type I interferon signaling pathway and plays a vital role in lupus.

ABSTRACT: Through genome-wide association studies (GWAS) and integrated expression quantitative trait locus (eQTL) analyses, numerous susceptibility genes ("eGenes", whose expressions are significantly associated with common variants) associated with systemic lupus erythematosus (SLE) have been identified. Notably, a subset of these eGenes is correlated with disease activity. However, the precise mechanisms through which these genes contribute to the initiation and progression of the disease remain to be fully elucidated. In this investigation, we initially identify SPATS2L as an SLE eGene correlated with disease activity. eSignaling and transcriptomic analyses suggest its involvement in the type I interferon (IFN) pathway. We observe a significant increase in SPATS2L expression following type I IFN

SUBMITTER: Chen M 

PROVIDER: S-EPMC11693870 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature