Cardiorespiratory fitness, hippocampal subfield morphology, and episodic memory in older adults.

ABSTRACT:

Objective

Age-related hippocampal atrophy is associated with memory loss in older adults, and certain hippocampal subfields are more vulnerable to age-related atrophy than others. Cardiorespiratory fitness (CRF) may be an important protective factor for preserving hippocampal volume, but little is known about how CRF relates to the volume of specific hippocampal subfields, and whether associations between CRF and hippocampal subfield volumes are related to episodic memory performance. To address these gaps, the current study evaluates the associations among baseline CRF, hippocampal subfield volumes, and episodic memory performance in cognitively unimpaired older adults from the Investigating Gains in Neurocognition Trial of Exercise (IGNITE) (NCT02875301).

Methods

Participa

SUBMITTER: Ripperger HS 

PROVIDER: S-EPMC11694150 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature