Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis.

ABSTRACT:

Objective

The objective of this study was to determine if baseline adiponectin, leptin, and resistin levels are associated with response to antirheumatic treatment in early rheumatoid arthritis (RA).

Methods

This study included 341 participants of the Nordic Rheumatic Diseases Strategy Trials and Registries trial with untreated early RA, randomized at baseline into four treatment arms: methotrexate combined with (1) prednisolone, (2) certolizumab, (3) abatacept, or (4) tocilizumab. Follow-up was up to 48 weeks. Adipokines were measured in plasma at baseline with enzyme-linked immunosorbent assay. The primary outcome for this report was the difference in remission (Clinical Disease Activity Index [CDAI] ≤2.8) over 48 weeks stratified by median adipokine levels.

Results

SUBMITTER: Vasileiadis GK 

PROVIDER: S-EPMC11694175 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature