BDNF and KIBRA Polymorphisms Are Related to Altered Resting State Network Connectivity in Middle Age.

ABSTRACT:

Background

Disease-modifying treatments for Alzheimer's disease (AD) may be more successful if interventions occur early, prior to significant neurodegeneration and subsequent to the onset of clinical symptoms, potentially during middle age. Polymorphisms within BDNF, COMT, and KIBRA have been implicated in AD and relate to episodic memory and executive functioning, two domains that decline early in AD.

Objective

The purpose of the current study was to use an endophenotype approach to examine in healthy, non-demented middle-aged adults the association between polymorphisms in BDNF, COMT, and KIBRA and functional connectivity within networks related to episodic memory and executive function (i.e., default mode network (DMN), executive control network (ECN), and frontoparietal

SUBMITTER: Blujus JK 

PROVIDER: S-EPMC11694220 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature