Outcomes of pregnancy in patients with chronic myeloid leukemia in the era of tyrosine kinase inhibitors.

ABSTRACT:

Background

Young female patients with chronic myeloid leukemia (CML) often face challenges becoming pregnant due to the teratogenicity of tyrosine kinase inhibitors (TKIs).

Methods

The authors conducted a nationwide survey of female patients with CML who experienced pregnancy between 2002 and 2020.

Results

Information for 70 pregnancies in 49 patients was obtained. There were three types of pregnancies: CML onset during pregnancy (n = 9), unplanned pregnancy mostly during treatment with a TKI (n = 25), and planned pregnancy during treatment-free remission (TFR) or treatment with interferon-alpha (IFN-α) (n = 36). The median duration from CML diagnosis to pregnancy in patients with planned pregnancy was significantly longer than that in patients with unplanned pregnanc

SUBMITTER: Kondo T 

PROVIDER: S-EPMC11694238 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature