Unlocking breast cancer in Brazilian public health system: Using tissue microarray for accurate immunohistochemical evaluation with limitations in subtyping.

ABSTRACT:

Background

Breast cancer (BC) is a significant burden on healthcare systems, especially in low- and middle-income countries where access to diagnosis and treatment is challenging.

Objectives

The purpose of this study was to assess the diagnostic accuracy and cost using tissue microarray (TMA) instead of traditional immunohistochemical (IHC) evaluation for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), and the proliferation marker Ki-67 and BC subtyping within the Brazilian public health system.

Design

This is a retrospective cohort study comparing TMA slides with traditional whole-slide evaluation for IHC markers in 242 BC cases.

Methods

We used formalin-fixed tissue blocks for TMA assembly. Clinical data and IHC sco

SUBMITTER: Ruppenthal RD 

PROVIDER: S-EPMC11694303 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature