Evaluating two live-attenuated vaccines against <i>Salmonella enterica</i> serovar Reading in turkeys: reduced tissue colonization and cecal tonsil transcriptome responses.

ABSTRACT: Vaccines that cross-protect across serovars of Salmonella enterica (Salmonella) would be a beneficial intervention against emerging and persistent Salmonella isolates of concern for the turkey industry. The 2017-2019 foodborne outbreak of Salmonella enterica serovar Reading (S. Reading) revealed the need for effective control of this serovar in turkey production. This study evaluated two live-attenuated Salmonella vaccines, an internally developed cross-protective vaccine and a commercially available vaccine, against an outbreak-associated strain of S. Reading in turkeys. At 1 day and 3 weeks of age, male turkey poults were either mock-vaccinated with phosphate buffered saline (PBS) or given one of the vaccines by oral gavage (primary and bo

SUBMITTER: Monson MS 

PROVIDER: S-EPMC11694450 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature