Ruthenium-catalyzed three-component tandem remote C-H functionalization of naphthalenes: modular and concise synthesis of multifunctional naphthalenes.

ABSTRACT: The prevalence of naphthalene compounds in biologically active natural products, organic ligands and approved drugs has motivated investigators to develop efficient strategies for their selective synthesis. C-H functionalization of naphthalene has been frequently deployed, but mainly involves two-component reactions, while multiple-component C-H functionalization for the synthesis of naphthalene compounds has thus far proven elusive. Herein, we disclose a versatile three-component protocol for the modular synthesis of multifunctional naphthalenes from readily available simple naphthalenes, olefins and alkyl bromides via P(iii)-assisted ruthenium-catalyzed remote C-H functionalization. This protocol not only tolerates various functional groups, but can be applied to many natural prod

SUBMITTER: Huang MG 

PROVIDER: S-EPMC11694486 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature