Deciphering a proteomic signature for the early detection of breast cancer from breast milk: the role of quantitative proteomics.

ABSTRACT:

Introduction

Breast cancer is one of the most prevalent cancers among women in the United States. Current research regarding breast milk has been focused on the composition and its role in infant growth and development. There is little information about the proteins, immune cells, and epithelial cells present in breast milk which can be indicative of the emergence of BC cells and tumors.

Areas covered

We summarize all breast milk studies previously done in our group using proteomics. These studies include 1D-PAGE and 2D-PAGE analysis of breast milk samples, which include within woman and across woman comparisons to identify dysregulated proteins in breast milk and the roles of these proteins in both the development of BC and its diagnosis. Our projected outlook for the use o

SUBMITTER: Whitham D 

PROVIDER: S-EPMC11694492 | biostudies-literature | 2024 Jan-Mar

REPOSITORIES: biostudies-literature