Meniran (Phyllanthus niruri L.) embedded zeolitic imidazolate framework (ZIF-8) nanoparticle for cancer chemotherapy: supported molecular docking analysis.

ABSTRACT: Cancer is among the leading causes of mortality worldwide. Natural bioactive compounds like Meniran (Phyllanthus niruri L.) have been the focus of extensive research due to their potent anticancer properties. Nevertheless, drug delivery strategies may be necessary to encapsulate bioactive compounds, thereby reducing their toxicity and enhancing their stability. Herein, we successfully synthesized Meniran extract incorporated zeolitic imidazolate framework (ZIF-8) nanoparticles for anticancer therapy. Meniran-incorporated ZIF-8 nanoparticles possess unique advantages including well-distributed nanoparticles with rhombic dodecahedrons and excellent pH-responsiveness. In vitro analysis showed that Meniran-incorporated ZIF-8 nanoparticles have anticancer activity towards HeLa cel

SUBMITTER: Ilhami FB 

PROVIDER: S-EPMC11694506 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature