Assessment of disease impact through health-related quality of life measurement in primary progressive aphasia.

ABSTRACT:

Introduction

Measurements of health-related quality of life (HRQoL) are important for capturing disease impact beyond physical health and relative to other diseases but have rarely been assessed in primary progressive aphasia (PPA).

Methods

HRQoL was characterized overall, by sex and subtype in PPA (n = 118) using the Health Utilities Index-2/3 (HUI2/3). Multiple linear regression assessed associations between HRQoL and language severity.

Results

Multi-attribute HUI2/3 summary scores indicated moderate to severe impairment. Scores did not differ by sex and were more severe for semantic than non-semantic PPA. Language severity scores showed significant associations with HUI multi-attribute scores and select single-attribute measures (hearing, sensation, cognitio

SUBMITTER: Hopkins T 

PROVIDER: S-EPMC11694525 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature