Alzheimer's disease drug development in an evolving therapeutic landscape.

ABSTRACT: The Alzheimer's disease (AD) research field has entered a new era, where our fundamental understanding of the pathophysiology of AD and advances in biomarkers have not only allowed for earlier, timely, and accurate detection and diagnosis of the disease, but that amyloid removal has been shown to be associated with signals of slowing cognitive and functional decline. Although recent FDA-approved amyloid plaque-lowering monoclonal antibody therapies have shifted the trajectory of AD, additional treatment options will be key to further slowing clinical decline or stopping disease progression. Thus, new and emerging therapies for AD have created an evolving therapeutic landscape. The Alzheimer's Association Research Roundtable (AARR) Spring meeting held on May 23-34, 2023, brought together a

SUBMITTER: Weninger S 

PROVIDER: S-EPMC11694530 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature