The association of dementia risk symptoms and functional activity in adults with Down syndrome.

ABSTRACT:

Introduction

Adults with Down syndrome (DS) have an increased risk of Alzheimer's disease (AD) dementia, often showing neuropathological indicators by age 40. Physical function and activities of daily living (ADLs) are understudied areas of function that may inform dementia risk. We investigated associations among age, physical function (gait/balance, grip strength, and lower extremity strength), ADLs, and dementia risk symptoms in adults with DS. We hypothesized that compromised physical function and lower independence with ADLs would be associated with an informant/caregiver-reported measure of dementia risk symptoms.

Methods

A secondary analysis for this cross-sectional study was completed using data from two academic research centers with 43 adults with DS (age 30 ± 12 y

SUBMITTER: Washington SE 

PROVIDER: S-EPMC11694531 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature