Designing and implementing the IDEAL Study: A randomized clinical trial of <i>APOE</i> genotype disclosure for late-onset Alzheimer's disease in an urban Latino population.

ABSTRACT:

Introduction

The Información de la Enfermedad de Alzheimer para Latinos (IDEAL) Study is a randomized clinical trial investigating the psychosocial, behavioral, and cognitive impacts of apolipoprotein E (APOE) genotype disclosure for late-onset Alzheimer's disease (AD) among Latinos.

Methods

We used address-based sampling to recruit English- and Spanish-speaking Latinos aged 40-64 living in northern Manhattan for a community-based Baseline Survey about their knowledge and opinions about AD. Participants eligible for the clinical trial were invited to complete an Introductory Session, including AD and genetics education and informed consent, before undergoing genotyping for APOE. Participants were then randomized to learn their risk of AD by age 85 (range

SUBMITTER: Wetmore JB 

PROVIDER: S-EPMC11694532 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature