Redefining Diagnostic Cut-Offs for the Indirect Water Deprivation Test.

ABSTRACT:

Objective

An incorrect diagnosis of arginine vasopressin deficiency and resistance (AVP-D and AVP-R) results in the potentially dangerous use of desmopressin in healthy individuals. The water deprivation test is a central diagnostic test in patients with polydipsia polyuria syndrome (PPS). This study aims to determine the effectiveness of the current interpretation of reference ranges.

Methods

This is a retrospective analysis of 135 patients who underwent a water deprivation test between August 2014 and August 2023. All patient diagnoses were reviewed, and variability and receiver operating characteristic (ROC) curves were determined for serum osmolality, serum sodium and urine osmolality.

Results

Serum sodium demonstrated reduced variability compared with serum osmol

SUBMITTER: Akkara Y 

PROVIDER: S-EPMC11694560 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature