Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents.

ABSTRACT: The study of brain connectivity, both functional and structural, can inform us on the development of psychopathology. The use of multimodal MRI methods allows us to study associations between structural and functional connectivity, and how this relates to psychopathology. This may be especially useful during childhood and adolescence, a period where most forms of psychopathology manifest for the first time. The current paper explores structure-function coupling, measured through diffusion and resting-state functional MRI, and quantified as the correlation between structural and functional connectivity matrices. We investigate associations between psychopathology and coupling in a transdiagnostic group of adolescents, including many treatment-seeking youth with relatively high levels of sym

SUBMITTER: Kanel D 

PROVIDER: S-EPMC11694614 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature