Design, synthesis, anticancer activity and molecular docking of quinoline-based dihydrazone derivatives.

ABSTRACT: Based on the biologically active heterocycle quinoline, we successfully synthesized a series of quinoline-based dihydrazone derivatives (3a-3d). ¹H NMR, ¹³C NMR, ESI-HRMS, IR, element analysis, UV/Vis spectroscopy and fluorescence spectroscopy were performed to comprehensively characterize their chemical structures, spectral properties and stability. Nitrosamine impurities were not detected in 3a-3d, and the systemic toxicological assessment indicated that the toxicity of 3a-3d was lower. Furthermore, their anticancer activity was evaluated by MTT, AO/EB double staining, apoptosis detection and ROS detection. The time-dependent UV/Vis spectra revealed that 3a-3d had good stability in solution. For all the newly synthesized compounds, cytotoxic activities were carried

SUBMITTER: Lu JX 

PROVIDER: S-EPMC11694625 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature