Binding profiles for 961 <i>Drosophila</i> and <i>C. elegans</i> transcription factors reveal tissue-specific regulatory relationships.

ABSTRACT: A catalog of transcription factor (TF) binding sites in the genome is critical for deciphering regulatory relationships. Here, we present the culmination of the efforts of the modENCODE (model organism Encyclopedia of DNA Elements) and modERN (model organism Encyclopedia of Regulatory Networks) consortia to systematically assay TF binding events in vivo in two major model organisms, Drosophila melanogaster (fly) and Caenorhabditis elegans (worm). These data sets comprise 605 TFs identifying 3.6 M sites in the fly and 356 TFs identifying 0.9 M sites in the worm, and represent the majority of the regulatory space in each genome. We demonstrate that TFs associate with chromatin in clusters termed "metapeaks," that larger metapeaks have characteristics of high-occupancy target (H

SUBMITTER: Kudron M 

PROVIDER: S-EPMC11694743 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature