Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplay.

ABSTRACT: Nucleotide sequences along a gene provide instructions to transcriptional and cotranscriptional machinery allowing genome expansion into the transcriptome. Nucleotide sequence can often be shared between two genes and in some occurrences, a gene is located completely within a different gene; these are known as host/nested gene pairs. In these instances, if both genes are transcribed, overlap can result in a transcriptional crosstalk where genes regulate each other. Despite this, a comprehensive annotation of where such genes are located and their expression patterns is lacking. To address this, we provide an up-to-date catalog of host/nested gene pairs in mouse and human, showing that over a tenth of all genes contain a nested gene. We discovered that transcriptional co-occurrence is often

SUBMITTER: Montibus B 

PROVIDER: S-EPMC11694760 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature