Integrated exposomic analysis of lipid phenotypes: Leveraging GE.db in environment by environment interaction studies.

ABSTRACT: Gene-environment interaction (GxE) studies provide insights into the interplay between genetics and the environment but often overlook multiple environmental factors' synergistic effects. This study encompasses the use of environment by environment interaction (ExE) studies to explore interactions among environmental factors affecting lipid phenotypes (e.g., HDL, LDL, and total cholesterol, and triglycerides), which are crucial for disease risk assessment. We developed a novel curated knowledge base, GE.db, integrating genomic and exposomic interactions. In this study, we filtered NHANES exposure variables (available 1999-2018) to identify significant ExE using GE.db. From 101,316 participants and 77 exposures, we identified 263 statistically significant interactions (FDR p < 0.1) in disco

SUBMITTER: Garao Rico AL 

PROVIDER: S-EPMC11694901 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature