Daily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults in a randomized, parallel arm, double-blind, placebo-controlled, pilot study.

ABSTRACT:

Objectives

Ketone bodies are endogenous metabolites produced during fasting or a ketogenic diet that have pleiotropic effects on aging pathways. Ketone esters (KEs) are compounds that induce ketosis without dietary changes, but KEs have not been studied in an older adult population. The primary objective of this trial was to assess the tolerability and safety of KE ingestion in a cohort of older adults.

Design

Randomized, placebo-controlled, double-blinded, parallel-arm trial (NCT05585762).

Setting

General community, Northern California, USA.

Participants

Community-dwelling older adults, independent in activities of daily living, with no unstable acute medical conditions (n = 30; M = 15, F = 15; age = 76 y, range 65-90 y) were randomized and n = 23 (M = 14, F =

SUBMITTER: Stubbs BJ 

PROVIDER: S-EPMC11695072 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature